A brief lecture on chimeric antigen receptor T cells (CAR-T cells) in the context of B-ALL therapy. I also discuss the limitations and risks of this potent immuno-oncologic therapy, and what I think is an interesting application of CRISPR technology in this space.
0:22 Background on B-ALL
6:09 Chimeric antigen receptors
14:02 CRISPR/ CAS9
18:11 CRISPR-derived CAR-T cells
19:12 Limitations of CAR-T cell therapy
25:19 CAR-T cell associated toxicities
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MEDICAL DISCLAIMER
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