#bioprinting #robotics #humanorgan

Researchers at Rensselaer Polytechnic Institute have developed a way to 3D print living skin, complete with blood vessels. This is a significant step toward creating grafts that are more like the skin our bodies produce naturally.

It provides some accelerated wound healing, but eventually it just falls off; it never really integrates with the host cells. A significant barrier to that integration has been the absence of a functioning vascular system in the skin grafts.

Researchers show that if they add key elements -- including human endothelial cells, which line the inside of blood vessels, and human pericyte cells, which wrap around the endothelial cells -- with animal collagen and other structural cells typically found in a skin graft, the cells start communicating and forming a biologically relevant vascular structure within the span of a few weeks.

In order to make this usable at a clinical level, researchers need to be able to edit the donor cells using something like the CRISPR technology, so that the vessels can integrate and be accepted by the patient's body.

This significant development highlights the vast potential of 3D bioprinting in precision medicine, where solutions can be tailored to specific situations and eventually to individuals.

But more work will need to be done to address the challenges associated with burn patients, which include the loss of nerve and vascular endings. But the grafts his team has created bring researchers closer to helping people with more discrete issues, like diabetic or pressure ulcers.

For those patients, these would be perfect, because ulcers usually appear at distinct locations on the body and can be addressed with smaller pieces of skin. Wound healing typically takes longer in diabetic patients, and this could also help to accelerate that process.


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