0:00 Warfarin overview
1:05 Mechanism of Warfarin Procoagulant state
3:06 Warfarin intoxication
5:24 Mechanism of skin necrosis
6:14 Risk factors of Warfarin induced skin necrosis
6:35 Treatment ( Protein C concentrate)
6:50 Prevention ( Heparin)
How warfarin initially increase coagulation. The mechanism of skin necrosis and gangrene. Why we give Heparin to prevent complications.
Nazarian, R. M., Van Cott, E. M., Zembowicz, A., & Duncan, L. M. (2009). Warfarin-induced skin necrosis. Journal of the American Academy of Dermatology, 61(2), 325-332.
Uworld step 2
Kakagia, D. D., Papanas, N., Karadimas, E., & Polychronidis, A. (2014). Warfarin-induced skin necrosis. Annals of dermatology, 26(1), 96-98.
Chan, Y. C., Valenti, D., Mansfield, A. O., & Stansby, G. (2000). Warfarin induced skin necrosis. Journal of British Surgery, 87(3), 266-272.
Mungalsingh, C. R., Bomford, J., Nayagam, J., Masiello, M., Ekeowa, U. I., & Webster, S. (2012). Warfarin-induced skin necrosis. Clinical medicine, 12(1), 90.
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