Retatrutide vs Ozempic. How is Retatrutide different than Ozempic, Wegovy, and Mounjaro. How Does Retatrutide Work? Demystifying The Role of GLP 1 Agonists.
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These medicines are so popular that all three injectables are currently in shortage in the U.S. Retatrutide is similar in that it is a once-weekly injection that also changes the way we eat, leading to early feelings of fullness and satiety.
So what makes Retatrutide any different?
Well first off, it has a triple G action. It is known as the triagonist. Which is different from the others. We saw with Mounjaro that it is a dual agonist—it has a GLP-1 portion and a GIP portion. Wegovy is just a GLP-1, But retatrutide binds and activates three receptors: the GLP-1, GIP and glucagon receptors.
This is what allows retatrutide to induce the glucose-dependent insulin release from the pancreas via GLP-1 receptors, enhance GLP-1-mediated effect through GIP receptors, AND increase energy expenditure through glucagon receptors.
Which is probably how you might end up losing more on this one than the others.
In the phase 2 clinical trials, for Eli Lily’s experimental treatment, whom are also the makers of Mounjaro. It shows us that the medication may be even more effective than Ozempic and other predecessors.
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338 adults with obesity who took retatrutide injections or a placebo for 48 weeks. At the end of the study, the people in the retatrutide group who took the highest dose at 12 milligrams a week) lost around 24% , compared to those in the placebo group, which lost 2%.
The majority of participants receiving the 12-mg dose had lost 20% or more of their baseline at 48 weeks and 26% had lost 30% or more of their original
Which is very remarkable since the data shows us that retatrutide results are higher than other popular choices.
Ozempic Shortage? Will Retatrutide Help With Supply?
The real question is, if retatrutide comes out on the market, will we finally see the end of the shortage?
And while you cant get your hands on retatrutide just yet because its still experimental. It shows a lot of promise. Right now its in phase 3, and phase III medicines for Obesity have a 44% phase transition success rate indication benchmark for progressing into Pre-Registration. Judging that Eli Lilly already has had there luck with tirzepatide being approved, it means you can start to see it popping up very soon. Within a year or two.
And I'm sure if youve been on any of the glp 1 agonist medicines, you know by now that lifestyle changes will still be absolutely the most important measures you take.
Im actually curious to hear more about how the side effects will be. If there actually a bit more tolerable than ozempic’s nausea, diarrhea, constipation, and vomiting. If it is, that will be a huge win for Eli Lilly. Because its the side effects that can make some not continue the whole course of treatment.
And Although Ozempic, Wegovy, and Rybelsus, are all Novo Nordisk products, which have obviously dominated the market in the past year, Eli Lilly has its own pipeline.
They are also working on orforglipron, which is a non peptide glp1 agonist, that’s even easier to produce and package. Which means it might make it possibly a lot cheaper and more affordable for some. Possibly ending the shortage altogether, since we will have a lot more options.
DISCLAIMER:
This video is for information only and should not be used for the diagnosis or treatment of medical conditions. Dr. Arsalan Aspires has used all reasonable care in compiling the information but make no warranty as to its accuracy. Always consult a doctor or other healthcare professional for diagnosis and treatment of medical conditions.
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