B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype.[1] They function in the humoral immunity component of the adaptive immune system by secreting antibodies.[1] Additionally, B cells present antigen (they are also classified as professional antigen-presenting cells (APCs)) and secrete cytokines.[1]
In mammals, B cells mature in the bone marrow, which is at the core of most bones.[2] In birds, B cells mature in the bursa of Fabricius, a lymphoid organ. (the "B" from B cells comes from the name of this organ), where it was first discovered by Chang and Glick,[2] and not from bone marrow as commonly believed.
B cell activation
Теги
b cellsCR1CR2Folicular dendritic cellsT-indepenent activationT-dependent activationHelper T cellsTfHCD19CD81B cell co receptorimmunologyadaptive immunityPRRB cell activationB cell differentiationlymph nodessrc kinasetyrosine kinaseb1 cellsCD35CD21ITAMSsubscapular sinus macrophagesBAFFC8DIL-6IL-15b cell activation in lymph nodest independent b cell activationt dependent b cell activationb cell activation and proliferation