Ronaldo did not feature in the Premier League match at Old Trafford, which ended in a 2-0 win for United.
Before full-time, the Portuguese superstar could be seen heading down the tunnel.
It was later reported that he left the stadium before the match had finished.
The Daily Mail have now claimed that Ronaldo refused to come on as a substitute against Spurs.
Journalist Chris Wheeler tweeted: "Cristiano Ronaldo REFUSED to come on as a substitute in Man Utd's win over Spurs before leaving Old Trafford early."
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