DISORDERS OF PLATELET FUNCTION
Some examples of disorders of platelet dysfunction are-
BERNARD SOULIER SYNDROME
GLAZMANN THROMBAESTHENIA
GREY PLATELET SYNDROME
HERMANSKY PUDLAK SYNDROME
CHEDIAK- HIGASHI SYNDROME
The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. The platelets arise from the fragmentation of the cytoplasm of megakaryocytes in the bone marrow and circulate in blood as disc-shaped anucleate particles for 7-10 days.
Under physiological circumstances, the resistance of the endothelial cell lining to interactions with platelets and coagulation factors prevents thrombosis. When endothelial continuity is disrupted and the underlying matrix is exposed, a coordinated series of events are set in motion to seal the defect (primary hemostasis).
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