House has an old lady hit on him who turns out to have Neurosyphilis.

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Season 1 Episode 8 "Poison"
House and his team investigate the mysterious poisoning of high-school student Matt Davis (John Patrick Amedori), until another teen is brought in with all of the same symptoms but almost nothing else in common with Matt. Eventually it is discovered that both youths bought very cheap pairs of jeans at a car boot sale. The jeans were exposed to high doses of pesticides.

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