Erika Hamilton, MD, Sarah Cannon Cancer Center, Nashville, TN, provides an overview of the preliminary data of the Phase Ib/II DESTINY-Breast07 (NCT04538742) dose-expansion study of trastuzumab deruxtecan (T-DXd) as monotherapy or combined with pertuzumab in patients with metastatic human epidermal growth factor receptor 2-positive (HER2+) breast cancer. The combination of T-DXd with pertuzumab demonstrated a manageable safety profile, although an increase in diarrhea was observed due to the addition of pertuzumab. The response rate between T-DXd as a monotherapy versus in combination with pertuzumab was not significantly different. However, the data for progression-free survival (PFS) is immature, as over ¾ of patients are still on ongoing treatment. This interview took place at the San Antonio Breast Cancer Symposium (SABCS) 2022 in San Antonio, TX.
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