What is the circadian rhythm and why is it important? People undoubtedly know that circadian rhythm is our biological clock. And the most common knowledge is that it controls the sleep-wake cycle. A lot of people are aware that the brain operates in circadian rhythms and at certain times of the day. When it's dark outside, increased production of melatonin puts someone into a sleepy state and their able to go to sleep for long periods of time. When they start to wake up in the morning and there's more light, melatonin production probably decreases, therefore allowing them to wake up.
Now, it's time to talk about it on a broader scale. Every cell in your body has its very own rhythm. That means there are different circadian rhythms. You have one that regulates your sleep-wake cycle, hormone secretion, body temperature, and more.
So what are these many other functions regulated by your circadian rhythms?
Find out how circadian rhythm works in this conversation between Mastering Diabetes and Dr. Satchin Panda.
- What is a circadian rhythm and why should people be aware of it?
- More hormones besides insulin that are regulated by circadian rhythm
- How circadian clock influences your brain
Satchidananda Panda explores the genes, molecules and cells that keep the whole body on the same circadian clock. A section of the hypothalamus called the suprachiasmatic nucleus (SCN) lies at the center of the body’s master clock and gets input directly from light sensors in the eyes, keeping the rest of the body on schedule. Panda discovered how these light sensors work, as well as how cellular timekeepers in other parts of the body function. He also uncovered a novel blue-light sensor in the retina that measures ambient light level and sets the time to go to sleep and wake up every day.
In the process of exploring how the liver’s daily cycles work, Panda found that mice who eat within a set amount of time (8-12 hours) resulted in slimmer, healthier mice than those who ate the same number of calories in a larger window of time, showing that when one eats may be as important as what one eats. If the benefits of this “time-restricted eating” (TRE) hold true in humans, it could have profound impacts on treating overeating disorders, diabetes and obesity. The circadian clock, he found, even mediates the immune system. Mice with a crucial circadian molecule missing had higher levels of inflammation in their bodies than other mice, suggesting that genes and molecules involved in the circadian clock could be drug targets for conditions linked to inflammation, such as infections or cancer. Complete Bio at: [ Ссылка ]
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