In this video, we delve into the findings of the AKIKI trial, a landmark study investigating the optimal timing for initiating renal replacement therapy (RRT) in ICU patients with acute kidney injury (AKI). Join us as we explore whether early or delayed RRT impacts survival rates and what this means for critically ill patients. We'll break down the study design, major points, and key results, and compare the AKIKI trial with other significant studies in this field. Whether you're a medical professional or a student, this video provides a comprehensive overview of RRT timing and its implications for patient care. Don't forget to like, subscribe, and leave your questions or comments below!

*Further Reading:*

1. Mehta RL & Renal-Replacement Therapy in the Critically Ill--Does Timing Matter?. N. Engl. J. Med. 2016. 375:175-6.
2. Zarbock A et al. Effect of Early vs Delayed Initiation of Renal Replacement Therapy on Mortality in Critically Ill Patients With Acute Kidney Injury: The ELAIN Randomized Clinical Trial. JAMA 2016. 315:2190-9.
3. Vinsonneau C & Monchi M Timing of Initiation of Renal Replacement Therapy in Critically Ill Patients With Acute Kidney Injury. JAMA 2016. 316:1497-1498.

*Reference:*

Gaudry S, et al. "Initiation strategies for renal-replacement therapy in the intensive care unit". The New England Journal of Medicine. 2016. 375(2):122-133.

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