A secondary analysis of data from the Worldwide Exploration of Renal Replacement Outcome Collaborative in Kidney Disease (WE-ROCK) registry highlighted greater rates of mortality among patients with late CRRT initiation, defined as more than 2 days from intensive care unit admission, compared to those who initiated therapy early (42.5% vs 33.7%; P = .01).
Of note, there were approximately 3% greater odds of major adverse kidney events at 90 days, including death, dialysis dependence, or persistent kidney dysfunction, for each 1-day delay in CRRT initiation (Odds ratio, 1.03; 95% Confidence interval, 1.02-1.04).
The editorial team of HCPLive Nephrology sat down with Katja Gist, DO, codirector of the Center for Acute Care Nephrology at Cincinnati Children's Hospital Medical Center, for additional insight into the use of CRRT in children and young adults, what is currently known about the best timing of therapy initiation, and what the present study adds to clinicians’ arsenal of knowledge about utilizing CRRT in this patient population.
Interview Highlights
0:00 Introduction
0:09 Background on optimal use, timing of CRRT
2:31 Study design
4:24 Key takeaways
6:31 Clinical significance
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