It is possible to mutilate yourself by smoking tobacco. The disease called Buerger's Disease or Thromboangiitis Obliterans can even cause you to lose your legs and arms completely. This disease only affects smokers and smokeless tobacco users, but its underlying mechanism is unknown.

The symptoms of Buerger's Disease are:
1. Pain in your arms or legs
2. One of your fingers or toes will become cold
3. Frozen Finger
4. Blood Blister
5. Dry Gangrene
6. Eating away of the tissue is the final stage.

You can prevent this by quitting smoking. Even if you already have this disease, quitting smoking will help you stop or slow down the progression of the disease.

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