▪ Marburg virus that cause marburg virus disease (MDV) also known as marburg hemorrhagic fever is a zoonotic virus that is initially transmitted from animals to humans. Marburg virus is clinically similar to the ebola virus and can lead to Marburg virus disease, formerly known as Marburg hemorrhagic fever.
▪ Early signs and symptoms of marburg virus disease (MVD) typically consist of fever, chills, headache, sore throat, weakness, and muscle aches. As it progresses, diarrhea, abdominal pain, nausea, vomiting, rash, and severe hemorrhagic signs and symptoms may also occur. In severe cases, confusion, seizures, shock, multiple organ failure, and death may follow.
▪ Marburg virus disease (MVD) may be diagnosed using throat and nasal swabs, cerebrospinal fluid samples, urine samples, and/or blood samples. ELISA testing, RT-PCR, IgM and/or IgG capture ELISA, and virus isolation by cell culture may also be used in diagnostic measures.
▪ Treatment of Marburg virus infection is limited to supportive care, typically after hospitalization, which includes rest, hydration, oxygen, and treatment of specific symptoms upon onset. Intravenous and/or oral fluids may be provided to replace lost fluids, stabilize electrolytes, and maintain blood pressure. Blood transfusions may also be provided to replace lost blood and clotting factors.
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