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The cycloaddition of azides and alkynes are a standard method for the synthesis of 1,2,3-triazoles. This laboratory experiment is a demonstration of the copper-catalyzed azide-alkyne cycloaddition (CuAAC) as developed by Sharpless, Fokin, and Meldal. This is a click reaction The reaction involves benzyl azide and phenyl acetylene to form 1-benzyl-4-phenyl-1,2,3-triazole as the product. The yield is 73%.
CuAAC click triazole synthesis - laboratory experiment
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