Ruben Mesa, MD, Levine Cancer Institute, Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston Salem, NC, discusses Phase III trials investigating the combination of the JAK inhibitor ruxolitinib with pelabresib (MANIFEST-2; NCT02158858) or navitoclax (TRANSFORM-1; NCT04472598) for patients with myelofibrosis (MF). The results from these trials demonstrate the superiority of this combination in reducing splenomegaly compared to ruxolitinib alone, signaling a shift from JAK inhibitor monotherapy towards combination therapy. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.

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