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Video Summary:
Pathophysiology of Parkinson’s disease was covered in first video. Antiparkinsonian drugs are levodopa, peripheral dopa decarboxylase inhibitors like carbidopa and benserazide, COMT inhibitors like tolcapone and entacapone, amantadine, dopamine receptor agonists like bromocriptine, pergolide, ropinirole and pramipexole, MAO-B inhibitors like selegiline and rasagiline and centrally acting antimuscarinic agents.
Levodopa is precursor of dopamine. So, when given to patients of Parkinson’s disease, remaining healthy neurons synthesize more dopamine from levodopa. This increases dopamine activity in brain and thus relieves symptoms. However, most of the levodopa is lost due to its peripheral conversion into dopamine by peripheral dopa decarboxylase and degradation by catechol o methyl transferase. To limit this loss DDC inhibitors like carbidopa and benserazide, and COMT inhibitors like tolcapone and entacapone can be used.

● Antiparkinsonian Drugs:
• AntiParkinsonian Drugs 1: Pathophysiology & Classification: [ Ссылка ]
• AntiParkinsonian Drugs 3: Amantadine, Dopamine Agonists, MAO-B Inhibitors, Antimuscarinic Agents: [ Ссылка ]
• Compilation of all videos on Antiparkinsonian Drugs: [ Ссылка ]

● Random videos related to Antiparkinsonian drugs
• Journey of Levodopa: [ Ссылка ]
• Dilemma of Dopamine: [ Ссылка ]

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DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorised websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.

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