Ageing is driven by a complex web of processes involving mutations in the genome as well as epigenetic changes. To investigate the interplay of these changes over time and their effects on critical cell processes associated with ageing, Villoo Morawala-Patell and Kashyap Krishnasamy (Avesthagen Ltd, India) performed long-read nanopore sequencing of PCR-free DNA, from human genomic samples taken 12 years apart. Comparisons of these samples' specific mutations and their methylation profiles helped shed light on the physiological processes driving ageing, and the role played by dynamic methylation.
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