A record-breaking fast and weight loss transformation. What goes on in your body and brain when you don’t eat for a year? And what does this teach us about prolonged fasting?

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#fasting #intermittentfasting #weightlosstransformation

Video chapters:
0:00 Record-breaking weight loss transformation
0:40 Why did he fast for a year? (& questions)
2:14 Why is fasting popular?
3:13 Prolonged fasting effects on the body
3:25 -Metabolic shift to ketosis & starvation mode
5:06 -Autophagy: the body eating itself
6:17 -Cardiovascular health effects
7:38 Prolonged fasting effects on the brain
9:00 -Mental health effects & psychology of fasting
11:22 -Relationship to food
12:21 How to do a prolonged fast safely
14:36 -How to prevent muscle loss
16:06 How long should you fast for?

Sources and further reading:

Stewart , Fleming LW. Features of a successful therapeutic fast of 382 days' duration. Postgrad Med J. 1973 Mar;49(569):203-9. doi: 10.1136/pgmj.49.569.203.

Wang Y, Wu R. The Effect of Fasting on Human Metabolism and Psychological Health. Dis Markers. 2022 Jan 5;2022:5653739. doi: 10.1155/2022/5653739.

Balasse EO, Féry F. Ketone body production and disposal: effects of fasting, diabetes, and exercise. Diabetes Metab Rev. 1989 May;5(3):247-70. doi: 10.1002/dmr.5610050304.

Mizushima, N, Komatsu M. “Autophagy: Renovation of Cells and Tissues.” Cell, vol. 147, no. 4, Nov. 2011, pp. 728–741, [ Ссылка ].

Masiero E et al. Autophagy is required to maintain muscle mass. Cell Metab. 2009 Dec;10(6):507-15. doi: 10.1016/j.cmet.2009.10.008.

Kitada, M., Koya, D. Autophagy in metabolic disease and ageing. Nat Rev Endocrinol 17, 647–661 (2021). [ Ссылка ]

Solianik R et al. Prolonged fasting outperforms short-term fasting in terms of glucose tolerance and insulin release: a randomised controlled trial. Br J Nutr. 2023 Nov 14;130(9):1500-1509. doi: 10.1017/S0007114523000557.

Saeed M, et al. (November 08, 2021) Intermittent Fasting: A User-Friendly Method for Type 2 Diabetes Mellitus. Cureus 13(11): e19348. doi:10.7759/cureus.19348

Malinowski B et al. Intermittent Fasting in Cardiovascular Disorders-An Overview. Nutrients. 2019 Mar 20;11(3):673. doi: 10.3390/nu11030673.

Youm YH et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015 Mar;21(3):263-9. doi: 10.1038/nm.3804. Epub 2015 Feb 16.

Saltiel AR, Olefsky JM. Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest. 2017 Jan 3;127(1):1-4. doi: 10.1172/JCI92035.

Mattson MP, et al. Intermittent metabolic switching, neuroplasticity and brain health. Nat Rev Neurosci. 2018 Feb;19(2):63-80. doi: 10.1038/nrn.2017.156. Epub 2018 Jan 11. Erratum in: Nat Rev Neurosci. 2020 Aug;21(8):445

“Ketogenic Diets Show Promise for Improving Mood and Research Suggests That the Diet May Possibly Benefit a Number of Mental Health Conditions.” Diabetes.co.uk, 15 Jan. 2019, www.diabetes.co.uk/keto/ketogenic-diet-and-mental-health.html.

Yudkoff, M et al. (2008), Ketosis and brain handling of glutamate, glutamine, and GABA. Epilepsia, 49: 73-75. [ Ссылка ]

Cherry, Kendra. “Self Efficacy: Why Believing in Yourself Matters.” Verywell Mind, 27 Feb. 2023, www.verywellmind.com/what-is-self-efficacy-2795954

Espelund U et al. Fasting unmasks a strong inverse association between ghrelin and cortisol in serum: studies in obese and normal-weight subjects. J Clin Endocrinol Metab. 2005 Feb;90(2):741-6. doi: 10.1210/jc.2004-0604

“The Story of Angus Barbieri, Who Went 382 Days without Eating.” Diabetes.co.uk, Feb. 2018, www.diabetes.co.uk/blog/2018/02/story-angus-barbieri-went-382-days-without-eating.

Fung, Jason. “Fasting and Re-Feeding Syndrome.” Diet Doctor, 29 Nov. 2016, www.dietdoctor.com/fasting-and-re-feeding-syndrome.

Ho KY et al. Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J Clin Invest. 1988 Apr;81(4):968-75. doi: 10.1172/JCI113450.

Jaspers, RT et al. (2017), Exercise, fasting, and mimetics: toward beneficial combinations?. The FASEB Journal, 31: 14-28. [ Ссылка ]

Wang, Yiren, Ruilin Wu. “The Effect of Fasting on Human Metabolism and Psychological Health.” Disease Markers, vol. 2022, 5 Jan. 2022, pp. 1–7, www.ncbi.nlm.nih.gov/pmc/articles/PMC8754590/, [ Ссылка ].

Title: What happens if you fast for a year?
Angus Barbieri prolonged fast fasting 1 year no food extended fasts autophagy ketosis starvation mode BDNF cardiovascular mental health self efficacy refeeding syndrome

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