Eventually everything wears out. One thing that happens as we get older - one mechanism of aging - is that we accumulate senescent cells. Senescent cells are like zombie cells. If senescent cells have some unique marker on their surface, then the immune system cells could seek them out and kill them. But the immune system needs to be taught to recognize the senescent cell marker. Thus, perhaps we can make a senescent cell vaccine.
Allen Lab Vlog 324, 12/27/2021
Further reading:
Ig Nobel Prize Winners:
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Primary source for 2009 winner in Medicine:
Unger, D. L. “Does Knuckle Cracking Lead to Arthritis of the Fingers?” Arthritis and Rheumatism 41, no. 5 (May 1998): 949–50. [ Ссылка ]
Kurtzgezagt on aging:
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Pop press coverage of Suda et al:
A new vaccine that alters senescent cells in a way that pushes the immune system into removing them [ Ссылка ]
A Potential Vaccine for Senescent Cells | Lifespan.io
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Suda, Masayoshi, Ippei Shimizu, Goro Katsuumi, Yohko Yoshida, Yuka Hayashi, Ryutaro Ikegami, Naomi Matsumoto, et al. “Senolytic Vaccination Improves Normal and Pathological Age-Related Phenotypes and Increases Lifespan in Progeroid Mice.” Nature Aging, December 10, 2021, 1–10. [ Ссылка ]
Yoshida, Shota, Hironori Nakagami, Hiroki Hayashi, Yuka Ikeda, Jiao Sun, Akiko Tenma, Hideki Tomioka, et al. “The CD153 Vaccine Is a Senotherapeutic Option for Preventing the Accumulation of Senescent T Cells in Mice.” Nature Communications 11, no. 1 (December 2020): 2482. [ Ссылка ]
