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A major challenge in the drug delivery field is to enhance transport of therapeutics across biological barriers such as the blood brain barrier (BBB), the small intestine, nasal, skin and the mouth mucosa. The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that prevents solutes in the circulating blood from non-selectively crossing into the extracellular fluid of the central nervous system where neurons reside. The placenta is the only organ linking two different individuals, mother and fetus, termed as blood-placental barrier. The functions of the blood-placental barrier are to regulate material transfer between the maternal and fetal circulation. The blood-testis barrier (BTB) is one of the tightest blood-tissue barriers in the mammalian body.
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