Hemolytic Anemia is a type of Anemia that is discussed in detail in this online Pathology lecture. Be knowledgeable about the hemolytic Anemia pathophysiology and a variety of erythrocyte membrane defects such as acanthocytosis as well as hereditary spherocytosis Pathology outlines. Moreover, immune and autoimmune hemolytic anemias, cold hemolysin disease, hypersplenism, and various other diseases are discussed in this V-Learning™.




Hemolytic Anemia occurs when Red Blood Cells are destroyed faster than their production. There are two mechanisms of hemolytic anemia pathophysiology. One is the intravascular hemolysis and the other is extravascular hemolysis. On the basis of the shape and component of the erythrocyte membrane that is responsible for the condition to arise, a variety of Erythrocyte membrane defects are discussed in this Pathology lecture.

Hereditary spherocytosis is a disorder that arises due to defect in Proteins of the erythrocyte membrane. It is characterized by splenomegaly, cholelithiasis, hemolytic crisis. Hereditary spherocytosis pathology outlines are also discussed along with its Pathogenesis.

Furthermore, hereditary elliptocytosis anemia pathology illustrates that on the Blood smear, elliptical-shaped erythrocytes are observed. This is followed by acanthocytosis, a rare condition that is defined as the condition in which abnormal red blood cells have spiny projections.

Immune and autoimmune hemolytic anemias are also made understandable for medical students. In both conditions, the immune system does not work properly. It recognizes red blood cells as unwanted substances and attacks them, causing them to die early. Warm and cold Antibodies autoimmune hemolytic anemia types are also discussed by highlighting their pathological slides.

Cold hemolysin disease also known as cold agglutinin disease is an autoimmune hemolytic anemia caused by cold-reacting autoantibodies. Hemolytic transfusion reactions are explained with the help of a diagram.

In addition to this, an explanation is given on hemolytic disease of the newborn that is characterized by high levels of bilirubin. The condition arises when the mother’s blood is not compatible with the fetus. Hypersplenism is discussed at the end of the lecture.

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