The Syrian army has launched intense attacks on the last areas under militant groups control in the Qalamoun mountains north of Damascus.
Attacks against militants' positions in the town of Nabuk began before dawn, the Syrian Observatory for Human Rights said.
The army decided to use overwhelming force to clear the region of armed militants.
Fierce battles are under way in Nabuk, which army troops entered on Thursday, the reports added.
The Syrian army is trying to capture the Qalamoun region, on the border with Lebanon, in a bid to sever militant groups' supply lines.
On November 19, troops seized the town of Qara, and on Thursday they announced the capture of nearby Deir Attiya, before moving on to Nabuk.
A Syrian security source said the recapture of Nabuk would leave only the Yabrud area and a few surrounding villages outside of government control.
"If this town is captured, all we'll have left is Yabrud and some other villages to completely block off the border with Lebanon," the source said.
Nabuk had been besieged by the army since Qara's fall on November 19. Neither food nor medicine has been able to enter Nabuk since then.
Qara, Deir Attiya and Nabuk all lie along the main highway between Damascus and Syria's third largest city Homs, adding to their strategic value for the government.
The Syrian army also has been intensely shelling militant positions in Daraa, this is responded by FSA and other groups storming checkpoints and barriers that are under control of the Syrian government.
Heavy fighting has been reported in Daraa city and on the outskirts in the last couple days.
Location of the area(Al-Qalamoun):
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Location of the area(Daraa):
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