Targeting the hypoxic tumor microenvironment has a broad impact in cancer epigenetics and therapeutics. Oxygen encapsulated nanosize carboxymethyl cellulosic nanobubbles were developed for mitigating the hypoxic regions of tumors to weaken the hypoxia-driven pathways and inhibit tumor growth. We show that hypomethylation in hypoxic regions of a tumor can be reverted to enhance cancer treatment by epigenetic regulation, using oxygen nanobubbles in the sub-100 nm size range, both, in vitro and in vivo. Oxygen nanobubbles were effective in significantly delaying tumor progression and improving survival rates in mice models. Further, significant hypermethylation was observed in promoter DNA region of BRCA1 due to oxygen nanobubble (ONB) treatment. The nanobubbles can also reprogram several hypoxia associated and tumor suppressor genes such as MAT2A and PDK-1, in addition to serving as an ultrasound contrast agent. Our approach to develop nanosized oxygen encapsulated bubbles as an ultrasound contrast agent for methylation reversal is expected to have a significant impact in epigenetic programming and to serve as an adjuvant to cancer treatment.
Do NOT forget to like 👍 this video and do NOT forget to subscribe to this YouTube channel to be notified of future uploads.
___________________________________________________
😉More info?
Visit [ Ссылка ] or write steve@teslatech.info
😎JOIN this channel at the $9.99 level to get access to MEMBER Only Videos:
[ Ссылка ]
😉To locate ALL CONFERENCEs hosted by TeslaTech Channel:
[ Ссылка ]
👀To locate SPEAKER videos on TeslaTech channel:
[ Ссылка ]
👏For Donations and other gifts use Paypal
[ Ссылка ]
Want to create live streams like this? Check out StreamYard: [ Ссылка ]
![](https://i.ytimg.com/vi/MyWiXNAi6zI/mqdefault.jpg)