Sheets of connective tissue divide the liver into thousands of small units called lobules. A lobule is roughly hexagonal in shape, with portal triads at the vertices and a central vein in the middle. The lobule is the structural unit of the liver and rather easy to observe. In contrast, the hepatic acinus is more difficult to visualize but represents a unit that is of more relevance to hepatic function because it is oriented around the afferent vascular system.
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