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In this video, Joanne discusses the 4 cycles that make up the methylation pathways; the methionine pathway, folate pathway, transsulfuration (or CBS) pathway, and the biopterin pathway.

Using this diagram, Joanne shows you how the cycles are linked as well as how environmental stressors (stress, diet, toxin exposure, gut issues) impact these pathways.

Joanne also discusses:
- The causes of low homocysteine
- Oxalates
- Sulfur issues and the importance of sulfation
- Histamine
- Glutathione
- How issues with the folate pathway and methionine pathway impact the biopterin pathway
- MTHFR gene mutation
- COMT enzyme

Reference: Seeking Health Educational Institute, Pathway Planner. Available from www.seekinghealth.com

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