India
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Cases, + 392,488 = 19,500,000
Deaths, + 3,689 = 215,542
Nevada, 7 cases of India variant, B.1.617
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Six in Washoe County
One in Churchill County
Heather Kerwin, epidemiology program manager
Washoe County residents, did not appear to have travelled
Centers for Disease Control and Prevention, B.1.617 not listed as VOI or VOC
Cambodia
Population, 15 million
Worst outbreak so far
All linked to B.1.1.7
Ban in inter-district travel
Mandatory masks
Night curfew
Enforced lockdowns since 5th April
Red zones
All markets in Phnom Penh closed
Food often not delivered by government
First dose, 1.3 million
Mostly Sinopharm with some Sinovac and COVAX AZ
US
Cases
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Vaccinations
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UK
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Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells
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Seattle and Atlanta
n = 254 COVID-19 patients
55% female, 45% male
Ages, 18-82
Longitudinally from early infection and for eight months
found a predominant broad-based immune memory response
Spike binding and neutralizing antibodies exhibited a bi-phasic decay
With an extended half-life of more than 200 days
Suggesting the generation of longer-lived plasma cells
Sustained IgG+ memory B cell response
Bodes well for a rapid antibody response upon virus re-exposure
Virus-specific CD4+ and CD8+ T cells were generated and maintained
Estimated half-life of 200 days
CD4+ T (helpers) cell response equally targeted several SARS-CoV-2 proteins
CD8+ T (cytotoxic) cell response preferentially targeted the nucleoprotein
Importance of including the nucleoprotein as a potential vaccine antigen
Follow up for next 3 years
