The endogenous anti-inflammatory Annexin A1 augments recovery following bladder outlet de-obstruction

Nose B1, Harper S1, Hughes F1, Purves J1

1. Division of Urology, Department of Surgery, Duke University Medical Center, Durham, NC

KEYWORDS: Voiding Dysfunction , Surgery, Basic Science, Animal Study, Benign Prostatic Hyperplasia (BPH)

Due in large part to damaging changes caused by inflammation during bladder outlet obstruction, bladder dysfunction persists in many patients following de-obstruction surgery. This clinically presents as persistent lower urinary tract symptoms and post-operative urinary retention. Our lab has extensively studied the mechanisms that trigger the bladder’s inflammatory response to obstruction, but the role of endogenous anti-inflammatories in the bladder, notably Annexin A1, has never been explored. In this study, we aim to assess the ability of Annexin A1 to enhance the resolution of inflammation following de-obstruction and improve functional bladder recovery.

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