If you take anti androgen drugs for acne, then you will want to watch this video to the very end.
Even if you don't take these drugs, this video has information that can still help you.
Drugs such as spironolactone, flutamide, bicalutamide and cyproterone acetate are anti androgen drugs used to treat acne.
These drugs work by inhibiting or blunting the androgen receptor.
Sometimes unwanted side effects come from anti androgen drugs.
So, I will show you an alternative.
And this alternative can help you even if you don't take these drugs.
With the focus on acne, how does the androgen receptor affect acne?
Bodo Melnik has a good technical discussion.
I have shown a picture from his scientific paper.
Let's talk about how to interpret this picture.
The lines that have arrows mean A causes or contributes to B.
The lines that end with a "T" mean that A inhibits or blunts B.
When B is inhibited, it works less.
Let's take a close look at the blue box labeled "AR" on the left hand side.
"AR" stands for androgen receptor.
And there is red circle with FoxO1 which is above it.
FoxO1 means forkhead box protein, but the name is not important.
FoxO1 to AR has a line with a "T", so FoxO1 inhibits AR.
The main point is that FoxO1 inhibits the androgen receptor
because that is the same thing that anti androgen drugs do.
That is, spironolactone, flutamide, bicalutamide and cyproterone acetate work by inhibiting the androgen receptor.
Now, let's look at what leads to FoxO1.
FoxO1 is inhibited by insulin and IGF-1.
If you read the details of Bodo Melnik's paper, you will find out that
dairy consumption causes IGF-1 via microRNA
In the picture, the 'M I R 21' is microRNA.
Insulin is also caused by carbohydrate consumption and generally by overconsumption of calories.
So, let's talk about using diet to inhibit the androgen receptor.
That is, if you want to use diet to mimic the effects of anti androgen drugs,
this is what you must do.
You reduce carbohydrate consumption and you eliminate dairy consumption.
Because carbohydrate and dairy consumption will inhibit FoxO1 - which we don't want.
If you let FoxO1 be uninhibited, then FoxO1 will then be allowed to inhibit the androgen receptor - which is what we want.
This picture helps you see the chemical pathways that connect diet to the androgen receptor.
I want to talk a little bit more about insulin.
In general, everything that helps insulin sensitivity will help acne.
Because having good insulin sensitivity will mean that your body needs less insulin.
Everything that causes insulin resistance will make acne worse.
Because insulin resistance means that your body needs more insulin.
As a general rule, eating too much raises insulin.
So changing the diet can do the same thing as spironolactone, flutamide, bicalutamide and cyproterone acetate.
Anti androgen drugs are not often used in males because of the potential for side effects.
Using diet instead will help avoid these side effects.
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If you are interested in specific actions to take to help with acne, then check out my website at goodacneadvice.com.
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Special Thanks to:
Video Production and Editing: Ivan Popovic of Unija
Voiceover: Colin Emberley
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