Misoprostol is a synthetic prostaglandin E1 analog, which is FDA approved only for the treatment and prevention of non-steroidal anti-inflammatory drug induced gastric ulcers.
However, it is used in combination with mifepristone for medically induced termination of pregnancy worldwide.
Clinicians also use it for the expectant management of missed and incomplete miscarriages.
At much smaller doses, it induces cervical ripening, and can be used to induce labor in full term pregnancies.
It is also useful in the treatment of postpartum uterine bleeding.
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