The scalefx-aa-fast shader in RetroArch is the very best upscaling shader I've seen for retro graphics - even better than 6xBRZ. Here are some screenshot and in-game comparisons, and how to set it in RetroArch.

Oh, and I nudged its sharpness up a tad by setting this in "Shader Parameters":

Deblur offset: 2.25
Deblur str.: 5.50
Smart deblur: 0.05

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