One of the severest blows of Aga Khani Ismailis efforts to disguise themselves as the 'second-largest' group of Shia Muslims was when the Shia Grand Ayatollah Allama Shaykh Muhammad Hussain Najafi clearly declared them outside of the fold of Shia Islam and Islam altogether.

Allama Muhammad Hussain Najafi is known in the Twelver circles as being as non-Takfiri (one who does not declare other sects as outside the fold of Islam) and earned further respect by being included int he lists of "The 500 Most Influential Muslims" in 2010 and 2011. He is also one of the only two Twelver Shi'i aalims from Pakistan who have been elevated to the status of marjiyyat.

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