Abstract: The precision nanomedicine significantly relies on the development of multifunctional nanomaterials to integrate cancer targeting, imaging, therapeutics and immune regulation. We report here near-infrared single molecular probe and nanoprobe for tumor microenvironment responsive multimodality imaging including in-situ click-labelling strategy, moreover, we intriguingly design oxygen nanocarriers and biomimetic drug delivery systems including a series of HSA/cancer cell/NK cell/T cell membrane-camouflaged nanoparticles, and realize cancer-targeting photo/sono-therapy including photodynamic therapy (PDT), photothermal therapy (PTT), and sonodynamic therapy (SDT). These multifunctional nanovectors show the great virtues in cancer homing and targeting, immune enhancement and regulation, and combination therapy. The resulted treatment will significantly suppress and even eradicate the cancer growth, inhibit the distance cancer and cancer metastasis. Such well-defined nanoparticles and nanorobots for smart drug delivery system would greatly improve the cancer-targeting theranostics with biodegradable control-releasing materials, precision drug delivery, real-time imaging in vivo, high-efficiency and safety therapy strategy.
Keywords: Nanomaterials, nanomedicine, biomimetic, molecular imaging, cancer theranostics.
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