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Dapsone is a prescription medicine used to treat the symptoms of Dermatitis Herpetiformis, Leprosy, Tuberculoid or Lepromatous Disease. Dapsone may be used alone or with other medications. Dapsone belongs to a class of drugs called Antileprosy Agents
Dapsone, also known as diaminodiphenyl sulfone, is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy.
Formula: C12H12N2O2S
Molar mass: 248.302 g/mol
CAS ID: 80-08-0
Trade name: Aczone, others
Metabolism: Liver (mostly CYP2E1-mediated)
Elimination half-life: 20 to 30 hours
Side effects
The most common side effects of Dapsone include:
stomach pain,
nausea,
vomiting,
headache,
dizziness or spinning sensation,
blurred vision,
ringing in your ears, and.
sleep problems (insomnia)
Moa
As an antimicrobial agent, dapsone is bacteriostatic in action. It inhibits the synthesis of dihydrofolic acid through by competing with para-aminobenzoic acid for the active site of dihydropteroate synthetase [35, 41], thus resembling the action of sulphonamides
Pregnancy
Aczone falls into category C. There are no well-controlled studies that have been done in pregnant women. Aczone should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby
Indications
Dapsone is indicated for a variety of conditions, both dermatologic and non-dermatologic. The FDA-approved indications are leprosy and dermatitis herpetiformis. The non-FDA approved indications include a wide range of dermatoses, as well as malaria and Pneumocystis (carinii) jiroveci prophylaxis and treatment.
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