What is Mounjaro?
Mounjaro is the trade name of a medication Tirzepatide which reduces glycemic levels and improves insulin sensitivity. It is sold by the pharma company Eli Lilly (NYSE: LLY). On May 13, 2022, the company announced that FDA has approved Tirzepatide to treat type 2 diabetes. It is a prescribed medicine, used once a week. Tirzepatide is available in doses of 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg. The appropriate dosage is decided and prescribed by your healthcare provider.
Mounjaro for Weight Loss:
Mounjaro (Tirzepatide) works for weight loss in both, diabetic (type-2) and non-diabetic obese patients. According to Eli Lilly, diabetic participants lost up to 25 lbs and non-diabetic obese participants lost up to 52 lbs in Mounjaro’s clinical trials named SURPASS and SURMOUNT.
Mounjaro weight loss in patients with type-2 diabetes:
Eli Lilly announced that in all their clinical trials, SURPASS 1 to 5, Mounjaro showed positive effects not only on managing type -2 diabetes but also on reducing body weight. It claimed that patients treated with Mounjaro lost on average 12 lbs to 25 lbs when they took a dosage between 5 mg to 15 mg. The trials lasted from 40 weeks to 104 weeks.
Mounjaro for weight Loss in patients without diabetes:
Mounjaro works for non-diabetic obese people as well. In separate clinical research, SURMOUNT-1, Eli Lilly claimed (on April 28, 2022) that Mounjaro (Tirzepatide) reduced up to 22.5% weight loss or 52 lbs in adults without diabetes in a 72-week clinical trial, in which 2,539 non-diabetic obese people participated.
Is Mounjaro approved by FDA as a weight loss medicine?
No. FDA has not yet approved Mounjaro to treat obesity (last updated: 7 Nov 2022). It is approved only for managing type-2 diabetes. FDA is currently in the process of reviewing it for the treatment of obesity. On Oct 6 2022, FDA granted Mounjaro a fast-track designation for the investigation of its effectiveness on adults with obesity. We will keep updated when FDA gives Mounjaro approval as a weight loss medication.
How does Mounjaro work for weight loss?
Mounjaro activates the body’s receptors for GIP and GLP-1. These two natural incretin hormones reduce the food intake, making you feel fuller for a longer time and also increase energy expenditure which ultimately causes weight reduction. GIP and GLP-1 have noticeable effects on markers of metabolic dysregulation such as body weight, glucose, and lipids.
Can I take Mounjaro to reduce weight?
You can take Mounjaro for weight loss only if your healthcare provider prescribes it and decides an appropriate dosage for you. Do not take it if you or any of your family have ever had thyroid cancer, Multiple Endocrine Neoplasia syndrome type 2, or allergy to any ingredients used in Mounjaro. You must be 18 years or older to take Mounjaro.







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