In this lab, we will demonstrate an overview of Click Chemistry.

Click chemistry is a reaction that occurs under mild aerobic conditions, utilizes benign solvents or no solvents at all, and requires no chromatographic purification.

For this experiment, you will be combining two compounds to form a carbon-nitrogen bond, which is a reaction essential to synthetic organic chemists. Reactions that form carbon-nitrogen bonds can be accomplished by several methods. These include nucleophilic substitution, reductive amination, and the Gabriel synthesis.

In addition to the organic reagents that are used in the previously mentioned reactions, there are also methods that utilize transition-metal catalysts to form carbon-nitrogen bonds. The manufacture of pharmaceuticals, polymers, and other synthetic materials often rely on metal catalysts to provide these products in an efficient manner with respect to cost and waste production, which aligns with the concept of click chemistry.

In this experiment, we will perform the synthesis of 1-Bezyl-4-Phenyl-1H-1,2,3-Triazole.
As shown in the video, to synthesize triazole, benzyl azide and phenylacetylene are reacted with each other, catalyzed by bromotris(triphenylphospine)copper(I), a metal catalyst. This reaction is considered to be a click chemistry transformation as it consists of no solvent, occurs under mild aerobic conditions, and does not require chromatographic purification.

Video Production: Dr. Xu's Research Group (Dr. Xu, Han, Emma, Nhu, and Emily).

Contents:

0:00 - Introduction
1:44 - Carrying out the reaction
3:00 - Reaction "work-up"
4:18 - Removing the solvent
5:10 - Behind the scene #001

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