In this 'How To' educational video , Riccardo Marconcini explains how to choose first line therapy for patients with advanced melanoma. Baseline evaluation including tumour burden staging, LDH, and biomarker testing should be performed to gather key information for prognosis grouping and treatment selection.

Reprinted from Lancet Oncology, 17 /12, Long GV et al., Factors predictive of response, disease progression, and overall survival after dabrafenib and trametinib combination treatment: a pooled analysis of individual patient data from randomised trials, Copyright (2016), with permission from Elsevier

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