Drug hypersensitivity can be divided into immediate and delayed reactions. This video reviews:
* the evaluation of immediate reactions to drugs, including the history, physical examination, and diagnostic testing procedures: immediate hypersensitivity skin testing and drug challenge
* preparation for, performance of, and interpretation of diagnostic tests
* penicillin allergy assessment in detail with other case examples including assessment of cephalosporin and vaccine hypersensitivity
From the JACI: In Practice article Positioning Drug Allergy Delabeling as a Critical Tool for Precision Medicine, Quality Improvement, and Public Health, by Kimberly G. Blumenthal and Elizabeth Phillips.
[ Ссылка ]30804-7/abstract
A separate video reviews the evaluation of delayed reactions to drugs: [ Ссылка ].
Additional Drug Allergy articles can be found at [ Ссылка ]
It has been over 75 years since the first use of penicillin and the first description of penicillin associated hypersensitivity reactions. Development of validated reagents for the diagnosis of immediate penicillin allergy led Allergy and Immunology (AI) specialists to play a key and active role in identifying individuals with true allergy, promoting drug avoidance and introducing desensitization for safe introduction of a drugs, such as penicillin, when necessary. Over the last several decades, the AI role has evolved to include the prevention, diagnosis, and treatment of drug hypersensitivity to any medication. In the last decade, the AI role has extended from expertise in the immunological diagnosis and treatment of patients with drug hypersensitivity to a new role as a steward to ensure that patients are not denied access to drugs to which they have a drug allergy label. Grown from data outlining the deleterious individual and public health consequences of an unverified penicillin allergy label, the term “delabeling” was introduced in 2013 and has fueled and promoted a “delabeling movement” in drug allergy. This delabeling movement is highlighted in the October 2020 issue of The Journal of Allergy and Clinical Immunology: In Practice [link to issue]. This issue details safe and effective approaches to penicillin allergy, multiple drug allergy syndromes, chemotherapy, immune checkpoint inhibitor reactions, and delayed T-cell mediated hypersensitivity reactions.
Also published with the October 2020 issue is a stand-alone supplement with a comprehensive compendium of diagnoses and management guidelines for the evaluation of allergy to more than 300 specific drugs. [link to issue]
See more from JACI: In Practice at [ Ссылка ]
The Journal of Allergy and Clinical Immunology: In Practice is an official journal of the American Academy of Allergy, Asthma & Immunology (AAAAI) [ Ссылка ]
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