Dr Laura Niedernhofer presents about various kind of DNA damage drives aging and the mechanism behind it in this clip.
Laura Niedernhofer, M.D., Ph.D., is the director of the Institute on the Biology of Aging & Metabolism (iBAM) at the University of Minnesota. Internationally recognized as an expert in the molecular and cellular basis of aging, Dr. Niedernhofer’s expertise is in how cellular senescence is regulated as well as the role of DNA repair during aging.
Research in the Niedernhofer lab is focused on studying the biology that drives aging. Being old is the greatest risk factor for most chronic diseases. Thus, we seek to identify aspects of the biology of aging that might be targeted therapeutically to keep the elderly healthier. The pillars of aging that are considered druggable include inflammation, adaptations to stress, autophagy and proteostasis, stem cell function, metabolism, epigenetics, macromolecular or organelle damage, and senescent cells. Dr. Niedernhofer’s expertise is in DNA damage and repair, and the role that endogenously produced DNA damage has in driving senescence and aging. We use genetic approaches to deplete DNA repair in mice enabling visualization of the health impact of DNA damage. Systemic depletion of a critical DNA repair enzyme ERCC1-XPF results in mice that age six times faster than normal animals, and led to the discovery of a human progeroid syndrome. Tissue-specific deletion of Ercc1 leads to murine models of age-related diseases including diabetes, heart disease and cognitive impairment. These mice have proven valuable for testing novel therapeutics rapidly.
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DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes.
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