In this week’s episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogramming. The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed.
#DavidSinclair #Longevity #Lifespan
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Timestamps:
00:00:00 Kicking Off Episode Five: Interventions on the Cutting Edge
00:02:39 Expressing Gratitude to the Sponsors
00:05:28 Testosterone Replacement Therapy
00:10:09 Human Growth Hormone
00:13:56 Peptide Supplementation and Regenerative Signaling
00:18:11 MOTS-c, Humanin, and Other Peptides
00:25:05 Exosome Therapy
00:31:56 A Primer on Stem Cells and Yamanaka Factors
00:37:59 Stem Cell Aging and Cord Blood Banking
00:41:42 The Therapeutic Potential of Stem Cells
00:43:37 Cellular Reprogramming
00:51:35 Resetting the Aging Clock
00:56:50 The Future Looks Bright
00:58:15 Next Week’s Episode: External Aging
00:58:36 Subscription and Support Options
Links:
Benefits and risks of testosterone treatment: [ Ссылка ]
Eunuchs are long-lived: [ Ссылка ]
Longevity is enhanced in mice lacking growth hormone: [ Ссылка ]
MOTS-c and age-dependent physical decline in mice: [ Ссылка ]
Fatty liver disease, obesity, and an analog of MOTS-C: [ Ссылка ]
Humanin regulates lifespan and healthspan in mice: [ Ссылка ]
Humanin ameliorates diabetes in mice: [ Ссылка ]
Mouse aging can be modulated via exosomes: [ Ссылка ]
Exosomes and ulcer healing in older mice: [ Ссылка ]
Generating induced pluripotent stem cells: [ Ссылка ]
Vision loss after ocular injections: [ Ссылка ]
Mesenchymal stem cells and human frailty: [ Ссылка ]
Restoring vision loss in older mice: [ Ссылка ]
Reversing epigenetic age in humans: [ Ссылка ]
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
