interviewed by Dr Mariela Glandt

Some say: you can produce short chain fatty acids
from bacterial fermentation of fiber
&
those short chain fatty acids can be taken up to
cells lining the colon, then be converted into ketones
as energy for that colonocyte,

thus creating more mucus for a
protective layer

colonocyte:
An endothelial cell of the large intestine & colon

endothelial cell:
one of the simple squamous (flattened) cells forming
the lining of blood & lymph vessels and inner layer
of the endocardium

Why not simply be in systemic ketosis?

Fiber is only fermented in a very small part of the colon

This area only allows fermented fiber access to
very limited colonocytes lining the bowel.
if pathology anywhere else in bowel,
this won't do a lick of good

But, if in systemic ketosis...
have ketones going around the whole intestine & colon
you would be in much better shape

Feeding bacteria wrong things can be very dangerous

clostridium difficile:
bacteria that, when overgrown, can release toxins
causing inflammation

pseudomembranous colitis:
disease caused by overgrowth of clostridium difficile,
perhaps from excess antibiotic use

Around 2000, Japan discovered ways to mass
manufacture trehalose.

this allows lowering the freezing point of dairy...
making a great additive for ice cream...
where introduced, correlated with
epidemic: pseudomembranous colitis
(clostridium difficile feeds off trehalose)

Feeding it trehalose allows it to out compete
other bacteria in the gut

from the journal: Nature

We don't want to feed the bad bacteria...

This whole notion of taking probiotics is bullocks:
Food causes bacteria to thrive or be suppressed

if you have a healthy probiotic but
don't feed it the right food,
they won't be sustained

Studies show that you can get a wholesale change
in your microbiome in 24 hours...
they die pretty quickly

In India, a condition called necrotizing enterocolitis...
an infection inside the intestines:
-in very young babies
-very dangerous

Tried synbiotic: put in probiotic to outcompete
the bad bacteria:
when combined with food: effective!

Traveller's diarrhea: take large amounts of probiotics,
continuously so they outcompete pathogenic bacteria
that you might ingest...
but:
-must be taken repeatly & in high doses
-only effective in short term
-can also cause gastrointestinal upset

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