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When To Take?
Most people find that taking DIM in the morning with a glass of water and a little food is the best way to go. Some women who have insomnia related to estrogen dominance, perimenopause, or menopause find that taking DIM at night helps them stay asleep longer – and even through the night.
DIM is short for diindolylmethane, a metabolite of indole-3-carbinol. DIM is a compound that can only be made from cruciferous vegetables. When broccoli, cauliflower, and other cruciferous vegetables are exposed to stomach acid after chewing, indole-3-carbinol is created, which is then converted into DIM.
While DIM can be derived from food, it would take eating a whole lot of broccoli to match what can be found in a supplement. That is why many people take a concentrated amount in the form of a supplement.
Supplementing our diets with DIM can shift the production of estrogen metabolites away from dangerous 16-hydroxy in favor of beneficial 2-hydroxy metabolites. Taking DIM in an absorbable formulation encourages active and healthy estrogen metabolism. DIM supports estrogen balance by increasing beneficial 2-hydroxy estrogens and reducing the unwanted 16-hydroxy variety.
Remember, 2-hydroxy is good; 16-hydroxy is bad.
PMS symptom improvement has been noted after beginning dietary supplementation with absorbable DIM. These results suggest DIM is able to correct the estrogen imbalance in PMS.
Everyone knows estrogen is an important hormone for reproduction in women. What is not often appreciated is that estrogen levels, though lower than those in women, are also essential in men. However, midlife changes in men result in excess estrogen production beyond its minimal essential level.
Like perimenopausal women, men experience a tendency to gain weight in midlife. Rising estrogen production can result, since fat cells contain the aromatase enzyme that converts testosterone into estrogen. Unmetabolized estrogen creates a vicious cycle resulting in further estrogen production. This occurs because fat is one source of more active aromatase enzymes, causing further estrogen production and continuing weight gain. An open label study of DIM in overweight men and women showed it promoted more efficient weight loss and more active fat metabolism.
In this regard, DIM is similar to green tea extract and spices like cayenne pepper. DiindolyImethane may have a role in helping to intervene with excess estrogen production associated with obesity and male aging. Besides weight gain, another aspect of early aging in men is prostate gland enlargement.
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Dr. Jinaan Jawad
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Carol Stream, IL 60188
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