Introduction video to the 2012 Sackler Lecture given by Professor Linda Partridge on the science of ageing at the University of Cambridge. The full lecture can be viewed at [ Ссылка ]
Ageing, because of its complexity, has long been regarded as intractable to experimental analysis and medical intervention. However, this pessimistic view has been overturned by the recent discovery that mutations in single genes can increase healthy lifespan in laboratory animals. Furthermore, the mechanisms at work are conserved over large evolutionary distances, with population--genetic association studies implicating similar processes in humans. Nutrient and stress--sensing pathways have proved to play a key role, through mechanisms that are the subject of current investigation. Modulation of the activity of these pathways can also ameliorate pathology in several animal models of human age--related diseases. These findings are pointing to the prospect of a broad--spectrum, preventative medicine for the diseases of ageing.
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