Hi. I’m Dr. Caplan. Dihydrotestosterone, DHT, is not just any androgen, it is the strongest androgenic steroid hormone made by the body. Its effects are anywhere from 5-10 times that of testosterone, but they are very localized. It is very important in the development of male genitalia in utero and secondary male traits in puberty, but that’s where most of its benefits seem to stop. In fact, in adults, it mostly just affects the tissues where it is made, mainly the prostate, skin, body hair, and scalp hair.
The DHT blood levels we can test is mostly made in the liver and brain, so it really doesn’t relate to what the local hormone is doing. DHT causes enlargement of the prostate and some prostate cancers, activation of sebaceous glands in the skin, and male-pattern hair loss. In women, it is associated with polycystic ovary syndrome. Medications to block it can reduce or relieve some of these issues. Some suggest using it to treat testosterone deficiency in men , but it is not available in the US, and I already get great results with enclomiphene and testosterone.
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