Chung-Han Lee, MD, PhD, Memorial Sloan Kettering Cancer Center, New York, NY, discusses the results of the the Phase II KEYNOTE-B61 (NCT04704219), which explored the use of lenvatinib plus pembrolizumab as a first-line treatment for advanced non-clear cell renal cell carcinoma (RCC). The study showed promising antitumor activity in a cohort of 158 patients with different non-clear cell RCC histologies, with an objective response rate (ORR) of 49% and a disease control rate (DCR) of 82%. The combination therapy demonstrated favorable outcomes and safety profiles, supporting its use as a first-line treatment option for non-clear cell RCC patients, regardless of histology. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

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