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Matt and guest Jonathan An, Assistant Professor of Oral Health Sciences at the University of Washington School of Dentistry, discuss oral health and its relationship to aging, including published studies involving rapamycin effects on oral health. This is a 3-part episode.

0:00 Are there any longevity interventions that are demonstrably effective for improving oral health?
1:55 What is the connection between aging and oral health?
4:09 What normal aging in a mouse looks like chronologically/studying aging in animal models
11:45 How Jonathan started out approaching the topic of periodontal disease in aged mice
14:00 Jonathan's study: Rapamycin treatment attenuates age-associated periodontitis disease in mice
28:12 Jonathan's study: Rapamycin rejuvenates oral health in aging mice
46:05 Are the effects of rapamycin on oral health shown in the paper systemic or local? Would rapamycin toothpaste work?
49:23 What Jonathan has learned since the rejuvenation study
54:06 What do we know about rapamycin's effects on oral health in humans?
59:00 An upcoming clinical trial of rapamycin's effects on periodontal disease in humans

Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa

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Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these videos helpful!

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