Title: Bayesian Adaptive Platform Clinical Trials in Acute Care Medicine: Next-Gen Tools for Evidence Generation?
Speaker: Dr. Patrick Lawler MD, MPH
Educational Objectives:
1. To consider why an evolving understanding of acute disease heterogeneity may necessitate evolving approaches to evidence evaluation
2. To review clinical trial designs focusing on Bayesian adaptive platform trials
3. To understand what heterogeneity of treatment effect is and how it may be accounted for by clinical trials
Biosketch: Dr. Lawler is a cardiologist and clinician-scientist at the Peter Munk Cardiac Centre at Toronto General Hospital, where he is the Associate Director for Clinical Trials and Translation. He is also an Assistant Professor of Medicine in the Division of Cardiology and Interdepartmental Division of Critical Care Medicine at the University of Toronto. He attended medical school at McGill and completed internal medicine residency training at the RVH, followed by clinical training in cardiovascular and critical care medicine at Brigham and Women’s Hospital and Massachusetts General Hospital at Harvard Medical School. He holds a master in public health from Harvard School of Public Health. His research interests lie at the intersection of acute cardiovascular disorders and systemic critical illness, and employ clinical trials, clinical epidemiology, and translational methods. This work extends his research training in preventive cardiology, inflammation, and metabolism at McGill and Brigham and Women’s Hospital, the latter where he trained as the Eugene Braunwald Scholar in Medicine, as well as at the Karolinska Institute in Stockholm where he trained in experimental cardiology as a Fulbright Scholar. Cross-cutting themes in his research relate to individualizing clinical care through biomarkers, clinical staging, and disease subphenotyping, as well as using systems medicine approaches to drive drug and diagnostic discovery in critical illness. Since 2017, his research has been funded through a total of $25,367,307 ($13,862,797 as PI/Co-PI) from CIHR, the NIH, the Province of Ontario, philanthropic foundations, and others. He has led research published in the New England Journal of Medicine, JAMA, the European Heart Journal, Circulation, Intensive Care Medicine, and elsewhere. He holds a National New Investigator career award from the Heart and Foundation of Canada. In April, he will join the Department of Medicine at the MUHC as a clinician-scientist, the Division of Cardiology as an attending staff physician in the Coronary Intensive Care Unit at the Glen, and McGill as an Assistant Professor.
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