Seems to work very well in 4K. Menus are problematic, but unimportant.
Might want to edit SE1\resource\ClientScheme.res (subscribe to "loose" beta in Steam to unpack files) to make close captions larger, as I've done in this video.
Lots of terrible aliasing in this game, but I couldn't fix it even with 4X SSAA so I didn't bother.
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