Fluorescently labeled specific antigen binding fragments, also known as Fabs, allow scientists to visualise transcription and histone modification dynamics in living embryos. In their recent Development paper, Yuko Sato, Hiroshi Kimura and collegues applied used Fabs to analyse the relationship between chromatin and transcription in zebrafish zygotic genome activation.

They found that histone H3K27 acetylation precedes active transcription in these embryos, and in doing do produced some beautiful movies that are collated here. This article is part of our 2019 Special Issue on Chromatin and Epigenetics. Check out the full issue here:

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