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Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders - a 2 minute Preview of the Experimental Protocol

Elke Gabriel, Jay Gopalakrishnan
University of Cologne, Center for Molecular Medicine Cologne; Medical School of University of Cologne, Institute for Biochemistry I;

Modeling human brain development has been hindered due to the unprecedented complexity of neural epithelial tissue. Here, a method for the robust generation of brain organoids to delineate early events of human brain development and to model microcephaly in vitro is described.

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